Research Interest

Our Research Interest

Research Interest

Isolation and Identification of Biologically Active Natural Products

In nature, we have numerous unknown compounds. Some of them have interesting biological activities and/or chemical structures. The aim of this program is to find such compounds. We are isolating tumer chemopreventing low molecular weight compounds from mashroom.

Identification of the components in “supplement” from natural sources and food additives

Many food additives and “supplement” are used for long time, but their components were still unclear. The aim of this program is to identify the component in such food for safety of our life.

List of selected publications

Harput, U. Sebnem; Calis, Ihsan; Saracoglu, Iclal; Donmez, Ali A.; Nagatsu, Akito.

Secondary metabolites from Phlomis syriaca and their antioxidant activities.

Turkish Journal of Chemistry (2006), 30(3), 383-390.

Tanabe, H.; Suzuki, H.; Nagatsu, A.; Mizukami, H.; Ogihara, Y.; Inoue, M.

Selective inhibition of vascular smooth muscle cell proliferation by coptisine isolated from Coptis rhizoma, one of the crude drugs composing Kampo medicines Unsei-in.

Phytomedicine (2006), 13(5), 334-342.

Ohno, Takamasa; Nagatsu, Akito; Nakagawa, Munehiro; Inoue, Makoto; Li, Yun-Mo; Minatoguchi, Shinya; Mizukami, Hajime; Fujiwara, Hisayoshi.

New sesquiterpene lactones from water extract of the root of Lindera strychnifolia with cytotoxicity against the human small cell lung cancer cell, SBC-3.

Tetrahedron Letters (2005), 46(50), 8657-8660.

Rana, Virendra S.; Rawat, Mohan S. M.; Pant, Geeta; Nagatsu, Akito.

Chemical constituents and antioxidant activity of Mallotus roxburghianus leaves.

Chemistry & Biodiversity (2005), 2(6), 792-798.

Hirakawa, Kazutaka; Yoshida, Mami; Nagatsu, Akito; Mizukami, Hajime; Rana, Virendra; Rawat, Mohan Singh Maniyari; Oikawa, Shinji; Kawanishi, Shosuke.

Chemopreventive action of xanthone derivatives on photosensitized DNA damage.

Photochemistry and Photobiology (2005), 81(Mar./Apr.), 314-319.

Tanaka, Rie; Sakano, Yuichi; Nagatsu, Akito; Shibuya, Masaaki; Ebizuka, Yutaka; Goda, Yukihiro.

Synthesis of digalactosyl diacylglycerols and their structure-inhibitory activity on human lanosterol synthase.

Bioorganic & Medicinal Chemistry Letters (2005), 15(1), 159-162.

Harput, Sebnem U.; Saracoglu, Iclal; Calis, Ihsan; Donmez, Ali A.; Nagatsu, Akito.

Secondary metabolites from Phlomis kotschyana.

Turkish Journal of Chemistry (2004), 28(6), 767-774.

Nagatsu, Akito; Itoh, Shizue; Tanaka, Rie; Kato, Setsuko; Haruna, Mitsumasa; Kishimoto, Keiichi; Hirayama, Hideki; Goda, Yukihiro; Mizukami, Hajime; Ogihara, Yukio.

Identification of novel substituted fused aromatic compounds, meshimakobnol A and B, from natural Phellinus linteus fruit body.

Tetrahedron Letters (2004), 45(30), 5931-5933.

Nagatsu, Akito; Sugitani, Tomochika; Mori, Yoshiko; Okuyama, Harumi; Sakakibara, Jinsaku; Mizukami, Hajime.

Antioxidants from rape (Brassica campestris var. Japonica hara) oil cake.

Natural Product Research (2004), 18(3), 231-239.

Harput, U. Sebnem; Nagatsu, Akito; Ogihara, Yukio; Saracoglu, Iclal.

Iridoid glucosides from Veronica pectinata var. glandulosa. Zeitschrift fuer Naturforschung, C:

Journal of Biosciences (2003), 58(7/8), 481-484.

Zhao, Changqi; Nagatsu, Akito; Hatano, Keiichiro; Shirai, Naohiro; Kato, Setsuko; Ogihara, Yukio.

New lignan glycosides from Chinese medicinal plant, Sinopodophillum emodi.

Chemical & Pharmaceutical Bulletin (2003), 51(3), 255-261.

Nagatsu, Akito; Isaka, Kimio; Kojima, Keisuke; Ondognii, Purev; Zevgeegiin, Oyun; Gombosurengyin, Purevsuren; Davgiin, Khishgee; Irfan, Baig; Iqubal, Choudhary Muhammad; Ogihara, Yukio.

New sesquiterpenes from Ferula ferulaeoides (STEUD.) Korovin, VI. Isolation and identification of three new dihydrofuro[2,3-b]chromones.

Chemical & Pharmaceutical Bulletin (2002), 50(5), 675-677.

Matsuno, Michiyo; Nagatsu, Akito; Ogihara, Yukio; Ellis, Brian E.; Mizukami, Hajime.

CYP98A6 from Lithospermum erythrorhizon encodes 4-coumaroyl-4'-hydroxyphenyllactic acid 3-hydroxylase involved in rosmarinic acid biosynthesis.

FEBS Letters (2002), 514(2-3), 219-224.

Isaka, Kimio; Nagatsu, Akito; Ondognii, Purev; Zevgeegiin, Oyun; Gombosurengyin, Purevsuren; Davgiin, Khishgee; Kojima, Keisuke; Ogihara, Yukio.

Sesquiterpenoid derivatives from Ferula ferulioides. V.

Chemical & Pharmaceutical Bulletin (2001), 49(9), 1072-1076.

Tanaka, Rie; Nagatsu, Akito; Mizukami, Hajime; Ogihara, Yukio; Sakakibara, Jinsaku.

Studies on chemical modification of monensin IX. Synthesis of 26-substituted monensins and their Na+ ion transport activity.

Chemical & Pharmaceutical Bulletin (2001), 49(6), 711-715.

Nagatsu, A.; Tanaka, R.; Mizukami, H.; Ogihara, Y.; Sakakibara, J.

Long-range 13C-1H coupling constants (3JC-H) of monensin sodium.

Tetrahedron (2001), 57(16), 3369-3372.

Tanaka, R.; Nagatsu, A.; Mizukami, H.; Ogihara, Y.; Sakakibara, J.

Studies on chemical modification of monensin VIII. Synthesis of 7-O-substituted-25-carboxymonensins and their Ca2+ ion transport activity.

Tetrahedron (2001), 57(15), 3005-3012.

Nagatsu, Akito; Tanaka, Rie; Hashimoto, Masayo; Mizukami, Hajime; Ogihara, Yukio; Sakakibara, Jinsaku.

Studies on chemical modification of monensin. Part 7. Synthesis and Ca2+ ion transport activity of 25-carboxylmonensin.

Tetrahedron Letters (2000), 41(15), 2629-2632.

Zhang, Hui Li; Nagatsu, Akito; Okuyama, Harumi; Mizukami, Hajime; Sakakibara, Jinsaku.

Sesquiterpene glycosides from cotton oil cake.

Phytochemistry (1998), 48(4), 665-668.

Zhang, Hui Li; Nagatsu, Akito; Watanabe, Toshihiro; Sakakibara, Jinsaku; Okuyama, Harumi.

Antioxidative compounds isolated from safflower (Carthamus tinctorius L.) oil cake.

Chemical & Pharmaceutical Bulletin (1997), 45(12), 1910-1914.

Nagatsu, Akito; Nakamura, Yukitaka; Takemoto, Kouya; Nagai, Shin-ichi; Ueda, Taisei; Hatano, Keiichiro; Sakakibara, Jinsaku; Hashimoto, Toshihiro; Asakawa, Yoshinori.

An usual fluoride-mediated oxidation of gitoxin.

Chemical & Pharmaceutical Bulletin (1996), 44(1), 258-60.

Nagatsu, Akito; Kajitani, Hitoshi; Sakakibara, Jinsaku.

Muscoride A: a new oxazole peptide alkaloid from freshwater cyanobacterium Nostoc muscorum.

Tetrahedron Letters (1995), 36(23), 4097-100.

Uemura, Daisuke; Chou, Tong; Haino, Takeharu; Nagatsu, Akito; Fukuzawa, Seketsu; Zheng, Shu-zhen; Chen, Hai-sheng.

Pinnatoxin A: a toxic amphoteric macrocycle from the Okinawan bivalve Pinna muricata.

Journal of the American Chemical Society (1995), 117(3), 1155-6.

Nagatsu, Akito; Watanabe, Miyako; Ikemoto, Kouji; Hashimoto, Masayo; Murakami, Nobutoshi; Sakakibara, Jinsaku; Tokuda, Harukuni; Nishino, Hoyoku; Iwashima, Akio; Yazawa, Kazunaga.

Synthesis and structure-antitumor-promoting activity relationship of monogalactosyl diacylglycerols.

Bioorganic & Medicinal Chemistry Letters (1994), 4(13), 1619-22.